Apolipoprotein A-IV inhibits experimental colitis
نویسندگان
چکیده
منابع مشابه
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
The inhibitory effects of vitamin D on colitis have been previously documented. Global vitamin D receptor (VDR) deletion exaggerates colitis, but the relative anticolitic contribution of epithelial and nonepithelial VDR signaling is unknown. Here, we showed that colonic epithelial VDR expression was substantially reduced in patients with Crohn's disease or ulcerative colitis. Moreover, targeted...
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The focus of this article is to review evidence that apolipoprotein A-IV (apo A-IV) acts as a satiety factor. Additionally, information regarding the general involvement of apo A-IV in the regulation of food intake and body weight is stated. Apo A-IV is a glycoprotein synthesized by the human intestine. In rodents, both the small intestine and liver secrete apo A-IV, but the small intestine is ...
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ApoA-IV was first described by Swaney, Reese, and Mer (1) as a component of rat HDL. Its presence has since been confirmed in dogs (2) as well as in man (3, 4). Apart from plasma, apoA-IV can also be demonstrated in human and rat mesenteric lymph (2, 5, 6), dog peripheral lymph (7), rat renal lymph (8), and rat bile (9). Despite the knowledge of apoA-IV's existence for over 10 years, relatively...
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Apolipoprotein A-IV is a member of the apo A-I/C-III/A-IV gene cluster. In order to investigate its hypothetical coordinated regulation, an acute phase was induced in pigs by turpentine oil injection. The hepatic expression of the gene cluster as well as the plasma levels of apolipoproteins were monitored at different time periods. Furthermore, the involvement of the inflammatory mediators' int...
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Nuclear factor of activated T cells (NFAT) plays a critical role in the development and function of immune and non-immune cells. Although NFAT is a central transcriptional regulator of T cell cytokines, its role in macrophage specific gene expression is less defined. Previous work from our group demonstrated that NFAT regulates Il12b gene expression in macrophages. Here, we further investigate ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2004
ISSN: 0021-9738
DOI: 10.1172/jci21233